1/8/2024 0 Comments Magna graecia tool![]() Heirloom tools you will pass on to the villagers yet to feel the joy of hearth keeping and homesteading! Hand-made, multi-functional, and down-right bad-ass, I held them in my hands and realized, if I buy this sickle, this maul, or this hoe I will never buy another one. These thoughts tumbled in my mind today as I had the chance to work with our hand tools. They come with more intention, more diligence, and more reliance on our village. But the practicalities of how to move forward, after we admit that this is not a sustainable way of life, come a bit slower. As delivery and mail service workers have stopped by the store today, the same questions are exchanged.will you continue to deliver, will there be delays, what happens next? Perhaps the question we need to be asking is, with recurring shortages like the one we are witnessing now, is this way of life sustainable? We all know the answer. But moments like this go beyond gas for personal vehicles. gas companies, pipelines, shortages, and delivery trucks, Villagers reminds us to trust our hands and this earth to sustain us. doi: 10.1126/ the world reminds us of our dependence on unknown and unnamed sources for our current ways of living, i.e. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. doi: 10.1371/journal.ppat.1007236.īaum A., Fulton B.O., Wloga E., Copin R., Pascal K.E., Russo V., Giordano S., Lanza K., Negron N., Ni M., et al. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19. Solerte S.B., Di Sabatino A., Galli M., Fiorina P. Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: Implication for development of RBD protein as a viral attachment inhibitor and vaccine. Tai W., He L., Zhang X., Pu J., Voronin D., Jiang S., Zhou Y., Du L. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., et al. These findings unveil a key antigenic site targeted by broadly neutralizing antibodies and pave the way to the design of pan-coronavirus vaccines.ĬOVID-19 SARS-CoV-2 variants VSVpp.SARS-2S conserved RBD region drug design peptides protein–protein docking. In parallel, we have selected and synthetized peptide sequences located within the highly conserved receptor-binding domain (RBD) of the S protein, and we found that RBD-based vaccines could better promote elicitation of high titers of neutralizing antibodies specific against the regions of interest, as confirmed by immunoinformatic methodologies and in vivo studies. On the basis of the involvement of the dipeptidyl peptidase 4 (DPP4), in addition to the angiotensin converting enzyme 2 (ACE2) receptor in the mechanism of virus entry, we analyzed peptides bearing DPP4 sequences by protein-protein docking and assessed their ability to block pseudovirus infection in vitro. In this work, we have validated the applicability of a peptide-based strategy focused on a preventive as well as a therapeutic purpose. Therefore, the development of additional vaccine platforms with improved supply and logistic profile remains a pressing need. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a global pandemic causing over 195 million infections and more than 4 million fatalities as of July 2021.To date, it has been demonstrated that a number of mutations in the spike glycoprotein (S protein) of SARS-CoV-2 variants of concern abrogate or reduce the neutralization potency of several therapeutic antibodies and vaccine-elicited antibodies. ![]() 10 Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV 89557, USA.9 IRCCS Neuromed, 86077 Pozzilli (IS), Italy.8 Renown Institute for Cancer, Nevada System of Higher Education, Reno, NV 89502, USA.7 Institute of Translational Pharmacology, CNR, 00133 Rome, Italy.6 SAFU-IRE, Regina Elena Cancer Institute, 00128 Rome, Italy.5 Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 3E1, Canada.4 The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada.Venuta", Viale Europa, 88100 Catanzaro, Italy. 3 Net4Science Academic Spin-Off, University 'Magna Graecia' of Catanzaro, Campus "S. ![]() 2 Department of Health Science, University 'Magna Graecia' of Catanzaro, Campus "S. ![]() 1 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
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